Hizentra Is a Subcutaneous Ig Therapy You Infuse Yourself

It's called a subcutaneous immunoglobulin, or SCIg, infusion, in which you infuse Ig treatment into the fatty tissue just below your skin's first layer. Do not infuse Hizentra into your vein.

  • A dose of Hizentra may be infused into multiple injection sites. Use up to 4 sites simultaneously or up to 12 sites consecutively per infusion. Injection sites should be at least 2 inches apart. Change the actual site of injection with each administration.
  • Recommended infusion sites include the stomach, thighs, upper arms, or hips. Your healthcare professional will teach you how to properly administer Hizentra
  • Sub-Q needles are smaller than IV needles. Depending on your size and weight, your doctor will recommend a needle as short as 4 mm or as long as 14 mm
Subcutaneous Infusion Sites

Self-Infusing at Home

Your healthcare provider will teach you how to infuse Hizentra over the course of several weeks. Make sure you're comfortable with the process before doing your own infusions.

Equipment You'll Need to Self-Administer Hizentra

Your nurse or specialty pharmacy will provide the necessary equipment to infuse Hizentra. Supplies include, but are not limited to: an infusion pump, syringe and needle, plastic tubing, container for syringe disposal, sterile gauze pad, and alcohol pads.

Hear Carla Duff, ARNP Discuss Self-Administration With Her Patients

“When [patients] leave... they are confident in their ability that the next week when they do their infusion, they can do it themselves”

- Carla Duff, ARNP

Hear Prescribers Discuss Topics Surrounding SCIg Therapy

Hizentra Patient Welcome Kit

Order the Complete Hizentra Welcome Kit

This kit provides important resources to help you start and stay on Hizentra. Your welcome kit includes:

  1. Voice2Voice Brochure
  2. Hizentra Patient Brochure
  3. Hizentra Step-by-Step Infusion Guide
  4. Hizentra Therapy Journal
  5. CSL Behring Assurance Brochure
  6. MyHizentra Infusion Manager App Brochure
  7. Prescribing Information, including Patient Product Information
  8. Additional Information

Keep track of your therapy with this convenient app

The MyHizentra® Infusion Manager app will alert you when it's time to infuse. The app can even send you reminders on all cloud-synced devices (desktop, laptop, mobile phone) as part of your regular calendar.

Like Hizentra itself, the Infusion Manager app is flexible and designed to fit your lifestyle. You can use the app to manage your own infusions, and/or those of someone for whom you are a caregiver. You can also customize how you enter your infusion schedule and the time at which you would like to be reminded.

The app makes it easy for you to record your infusions, including scanning the QR code of each vial and giving you a place to write notes on each infusion. You’ll be able to review the digital record of your past infusions at any time.

Important Safety Information
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Important Safety Information

WARNING: Thrombosis (blood clots) can occur with immune globulin products, including Hizentra. Risk factors can include: advanced age, prolonged immobilization, a history of blood clotting or hyperviscosity (blood thickness), use of estrogens, installed vascular catheters, and cardiovascular risk factors.

If you are at high risk of blood clots, your doctor will prescribe Hizentra at the minimum dose and infusion rate practicable and will monitor for signs of clotting events and hyperviscosity. Always drink sufficient fluids before infusing Hizentra.

See your doctor for a full explanation, and the full prescribing information for complete boxed warning.

Hizentra®, Immune Globulin Subcutaneous (Human), 20% Liquid, is a prescription medicine used to treat:

  • Primary immune deficiency (PI) in patients 2 years and older
  • Chronic inflammatory demyelinating polyneuropathy (CIDP) in adults

Treatment with Hizentra might not be possible if your doctor determines you have hyperprolinemia (too much proline in the blood), or are IgA-deficient with antibodies to IgA and a history of hypersensitivity. Tell your doctor if you have previously had a severe allergic reaction (including anaphylaxis) to the administration of human immune globulin. Tell your doctor right away or go to the emergency room if you have hives, trouble breathing, wheezing, dizziness, or fainting. These could be signs of a bad allergic reaction.

Inform your doctor of any medications you are taking, as well as any medical conditions you may have had, especially if you have a history of diseases related to the heart or blood vessels, or have been immobile for some time. Inform your physician if you are pregnant or nursing, or plan to become pregnant.

Infuse Hizentra under your skin only; do not inject into a blood vessel. Self-administer Hizentra only after having been taught to do so by your doctor or other healthcare professional, and having received dosing instructions for treating your condition.

Immediately report to your physician any of the following symptoms, which could be signs of serious adverse reactions to Hizentra:

  • Reduced urination, sudden weight gain, or swelling in your legs (possible signs of a kidney problem).
  • Pain and/or swelling or discoloration of an arm or leg, unexplained shortness of breath, chest pain or discomfort that worsens on deep breathing, unexplained rapid pulse, or numbness/weakness on one side of the body (possible signs of a blood clot).
  • Bad headache with nausea; vomiting; stiff neck; fever; and sensitivity to light (possible signs of meningitis).
  • Brown or red urine; rapid heart rate; yellowing of the skin or eyes; chest pains or breathing trouble; fever over 100°F (possible symptoms of other conditions that require prompt treatment).

Hizentra is made from human blood. The risk of transmission of infectious agents, including viruses and, theoretically, the Creutzfeldt-Jakob disease (CJD) agent and its variant (vCJD), cannot be completely eliminated.

The most common side effects in the clinical trials for Hizentra include redness, swelling, itching, and/or bruising at the infusion site; headache; chest, joint or back pain; diarrhea; tiredness; cough; rash; itching; fever, nausea, and vomiting. These are not the only side effects possible. Tell your doctor about any side effect that bothers you or does not go away.

Before receiving any vaccine, tell immunizing physician if you have had recent therapy with Hizentra, as effectiveness of the vaccine could be compromised.

Please see full prescribing information for Hizentra, including boxed warning and the patient product information.

You are encouraged to report negative side effects of prescription drugs to the FDA. Visit www.fda.gov/medwatch, or call 1-800-FDA-1088.

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Patient/Caregiver Using Hizentra Self-Administration
CSL Behring
Hizentra is manufactured by CSL Behring AG and distributed by CSL Behring LLC.
Hizentra® and MyHizentra® are registered trademarks of CSL Behring AG.
Biotherapies for Life® is a registered trademark of CSL Behring LLC.
CSL Behring AssuranceSM, IgIQSM, and Premier StartSM are service marks of CSL Behring LLC.
Voice2Voice® is a registered trademark of CSL Behring GmbH.
© 2018 CSL Behring LLC. The product information presented on this site is intended for US residents only. HIZ-0316-MAR18